Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14940507 | 0.83 | NFKB1 (0.53) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL1465687 | 0.80 | RAB9A (0.49) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL7678043 | 0.80 | MAPT (0.59) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL9048746 | 0.78 | ALDH1A1 (0.56) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL11636386 | 0.71 | ALDH1A1 (0.47) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL22628619 | 0.71 | RAB9A (0.65) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL11564238 | 0.71 | RAPGEF4 (0.61) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL22853792 | 0.71 | LMNA (0.64) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL27889688 | 0.70 | RAB9A (0.61) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL7683483 | 0.70 | MAPT (0.47) | MAPTALDH1A1KMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6342503-B1 | ANTIDEPRESSANTS, EATING DISORDERS | DUPONT PHARMACEUTICALS COMPANY | 2002-01-29 | — | — | US | disclosed |
| US-6107301-A | PSYCHOLOGICAL DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010506-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-04-20 | — | — | WO | disclosed |