Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK1 | P06870 | 1/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565285 | 0.87 | NPC1 (0.49) | NPC1RAB9ABRAFHDAC1EGLN1 | |
| SCHEMBL7677130 | 0.82 | PRSS1 (0.41) | KLK1KLK5PRSS1F2PRSS2 | |
| SCHEMBL7670696 | 0.80 | KMT2A (0.44) | KLK1KLK5NPC1RAB9APRSS1 | |
| SCHEMBL6563625 | 0.79 | PRSS1 (0.43) | RAB9APRSS1F2PRSS2PRSS3 | |
| SCHEMBL7670899 | 0.79 | PRSS1 (0.43) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7674188 | 0.78 | EGLN1 (0.44) | KLK1KLK5PRSS1F2PRSS2 | |
| SCHEMBL6563773 | 0.78 | LDHA (0.42) | KLK1KLK5PRSS1F2PRSS2 | |
| SCHEMBL7676492 | 0.77 | CCNA2 (0.41) | NPC1RAB9APRSS1F2PRSS2 | |
| SCHEMBL6563461 | 0.75 | PRSS1 (0.49) | KLK1KLK5PRSS1F2PRSS2 | |
| SCHEMBL6565256 | 0.75 | AKR1C3 (0.44) | KLK1KLK5PRSS1F2PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-1140802-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM KG (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035859-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-06-22 | — | — | WO | disclosed |