Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680945 | 0.83 | PTPRC (0.44) | LMNAALDH1A1MAPT | |
| SCHEMBL7678604 | 0.80 | PTGES (0.47) | PTGESALOX5SMN1; SMN2TSHRCYP4F2 | |
| SCHEMBL1244177 | 0.78 | ALDH1A1 (0.45) | SMN1; SMN2ALOX15KMT2AMEN1ALDH1A1 | |
| SCHEMBL1242308 | 0.74 | HPGD (0.43) | SMN1; SMN2TSHRALOX15KMT2AMEN1 | |
| SCHEMBL1244702 | 0.73 | TUBB4A (0.44) | SMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL364035 | 0.70 | MAPK1 (0.55) | PTGESALOX5SMN1; SMN2TSHRCYP4F2 | |
| SCHEMBL18796672 | 0.69 | PDE3B (0.73) | PTGESALOX5SMN1; SMN2TSHRCYP4F2 | |
| SCHEMBL10963637 | 0.69 | KDM4E (0.51) | PTGESALOX5SMN1; SMN2TSHRLMNA | |
| SCHEMBL5113224 | 0.68 | PARP15 (0.48) | SMN1; SMN2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL5214867 | 0.67 | ALOX5 (0.47) | PTGESALOX5SMN1; SMN2TSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479527-B1 | Bicyclic pyrrole derivatives as MCP-1 inhibitors | ASTRAZENECA UK LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |