Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7682574 | 0.83 | KDM4A (0.43) | MEN1ALDH1A1KMT2A | |
| SCHEMBL7682599 | 0.80 | PTGES (0.47) | PTGESALOX5SMN1; SMN2TSHRLMNA | |
| SCHEMBL364035 | 0.70 | MAPK1 (0.55) | PTGESALOX5SMN1; SMN2TSHRLMNA | |
| SCHEMBL18796672 | 0.69 | PDE3B (0.73) | PTGESALOX5SMN1; SMN2TSHRLMNA | |
| SCHEMBL823402 | 0.68 | SMN1; SMN2 (0.46) | PTGESALOX5SMN1; SMN2TSHRLMNA | |
| SCHEMBL15931903 | 0.67 | MAPT (0.48) | PTGESALOX5SMN1; SMN2TSHRLMNA | |
| SCHEMBL5214867 | 0.67 | ALOX5 (0.47) | PTGESALOX5SMN1; SMN2TSHRMAPT | |
| SCHEMBL902329 | 0.66 | PDE4A (0.47) | PTGESALOX5SMN1; SMN2TSHRLMNA | |
| SCHEMBL8938451 | 0.66 | ALDH1A1 (0.68) | MAPTALOX15MEN1ALDH1A1KMT2A | |
| SCHEMBL18919725 | 0.66 | ALOX5 (0.50) | PTGESALOX5SMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479527-B1 | Bicyclic pyrrole derivatives as MCP-1 inhibitors | ASTRAZENECA UK LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |