Sugi Predict

Sugi Predict / Compounds / SCHEMBL7683672

SCHEMBL7683672

SCHEMBL7683672

CC(C)(C)[Si](C)(C)OC1CC2CC(=O)CC1N2Cc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ THRB P10828 2/20 0.41
▸ KMT2A Q03164 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ SLC6A4 P31645 3/20 0.39
▸ SLC6A3 Q01959 2/20 0.39
▸ CHRM2 P08172 1/20 0.35
▸ CHRM4 P08173 1/20 0.35
▸ CHRM5 P08912 1/20 0.35
▸ NR1H2 P55055 1/20 0.33
▸ ALDH1A1 P00352 2/20 0.33
▸ GAA P10253 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16249881 0.84 SLC6A4 (0.42) THRBKMT2AL3MBTL1SLC6A4SLC6A3
SCHEMBL16237040 0.82 CHRM2 (0.40) THRBKMT2AL3MBTL1SLC6A4SLC6A3
SCHEMBL22324118 0.82 CHRM2 (0.40) THRBKMT2AL3MBTL1SLC6A4SLC6A3
SCHEMBL16237798 0.82 THRB (0.35) THRBKMT2AL3MBTL1SLC6A4SLC6A3
SCHEMBL16237799 0.82 THRB (0.35) THRBKMT2AL3MBTL1SLC6A4SLC6A3
SCHEMBL16249858 0.81 THRB (0.38) THRBKMT2AL3MBTL1SLC6A4SLC6A3
SCHEMBL16240502 0.78 NR1H2 (0.41) THRBKMT2AL3MBTL1SLC6A4SLC6A3
SCHEMBL28650837 0.78 NR1H2 (0.41) THRBKMT2AL3MBTL1SLC6A4SLC6A3
SCHEMBL7688348 0.78 CHRM2 (0.36) THRBKMT2AL3MBTL1SLC6A4SLC6A3
SCHEMBL7690579 0.78 MEN1 (0.47) THRBKMT2ACHRM2CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12522597-B2 Methods and compositions for modulating splicing SKYHAWK THERAPEUTICS, INC. (US) 2026-01-13 — — US disclosed
US-12509460-B2 Methods and compositions for modulating splicing SKYHAWK THERAPEUTICS, INC. (US) 2025-12-30 — — US disclosed
CN-119638696-A Methods and compositions for modulating splicing 斯基霍克疗法公司 2025-03-18 — — CN disclosed
US-20230054781-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. 2023-02-23 — — US disclosed
US-20230020922-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. 2023-01-19 — — US disclosed
CN-114126613-A Methods and compositions for modulating splicing 斯基霍克疗法公司 2022-03-01 — — CN disclosed
EP-3921311-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING Skyhawk Therapeutics, Inc. (US) 2021-12-15 — — EP disclosed
EP-3920926-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING Skyhawk Therapeutics, Inc. (US) 2021-12-15 — — EP disclosed
EP-3920928-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING Skyhawk Therapeutics, Inc. (US) 2021-12-15 — — EP disclosed
CN-113661162-A Methods and compositions for modulating splicing 斯基霍克疗法公司 2021-11-16 — — CN disclosed
WO-2014184328-A1 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION F. HOFFMANN-LA ROCHE AG (CH) 2014-11-20 — — WO disclosed
US-20020061913-A1 Bicyclic amine derivatives SYNGENTA LIMITED (GB) 2002-05-23 — — US disclosed
US-6294545-B1 INSECTICIDES SYNGENTA LIMITED (GB) 2001-09-25 — — US disclosed
US-6291474-B1 COMBATING AND CONTROLLING INSECT, ACARINE OR NEMATODE PESTS ZENECA LIMITED (GB) 2001-09-18 — — US disclosed
US-6177442-B1 INSECTICIDES; PESTICIDES; MITICIDES; NEMATOCIDES ZENECA LIMITED (GB) 2001-01-23 — — US disclosed
EP-1033914-A1 BICYCLIC AMINES AND THEIR USE AS INSECTICIDES ZENECA LIMITED (GB) 2000-09-13 — — EP disclosed
US-5968947-A INSECTICIDES, ACARICIDES, NEMATOCIDES ZENECA LIMITED (GB) 1999-10-19 — — US disclosed
EP-0944627-A1 8-AZABICYCLO 3.2.1]OCTANE-, 8-AZABICYCLO 3.2.1]OCT-6-ENE-, 9-AZABICYCLO 3.3.1]NONANE-, 9-AZA-3-OXABICYCLO 3.3.1]NONANE- AND 9-AZA-3-THIABICYCLO 3.3.1]NONANE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INSECTICIDES ZENECA LIMITED (GB) 1999-09-29 — — EP disclosed
WO-1999026478-A1 BICYCLIC AMINES AND THEIR USE AS INSECTICIDES ZENECA LIMITED (GB) 1999-06-03 — — WO disclosed
WO-1998025924-A1 8-AZABICYCLO[3.2.1]OCTANE-, 8-AZABICYCLO[3.2.1]OCT-6-ENE-, 9-AZABICYCLO[3.3.1]NONANE-, 9-AZA-3-OXABICYCLO[3.3.1]NONANE- AND 9-AZA-3-THIABICYCLO[3.3.1]NONANE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INSECTICIDES ZENECA LIMITED (GB) 1998-06-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230020922-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING RBM17, SF3B1, SNRPA1 THRB 3362/4885KMT2A 2256/4885L3MBTL1 176/4885
US-12509460-B2 Methods and compositions for modulating splicing SF3B1, RTCB, RBM17 THRB 1010/4885KMT2A 2279/4885L3MBTL1 384/4885
US-20020061913-A1 Bicyclic amine derivatives ADRA1D, TAAR1, ADRA1A THRB 1627/4885KMT2A 526/4885L3MBTL1 390/4885
US-20230054781-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING RBM17, SF3B1, SF3B5 THRB 3188/4885KMT2A 2420/4885L3MBTL1 231/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.