Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368640 | 0.73 | ALDH1A1 (0.54) | MAPK8 | |
| SCHEMBL7374722 | 0.73 | KDM4E (0.44) | MAPK14LMNA | |
| SCHEMBL7370850 | 0.71 | MAPK8 (0.43) | MAPK14MAPK8 | |
| SCHEMBL7367309 | 0.70 | MEN1 (0.63) | MAPK8CYP11B1CYP11B2LMNA | |
| SCHEMBL7809649 | 0.70 | ABCB1 (0.54) | ABCB1 | |
| SCHEMBL858688 | 0.69 | MET (0.52) | DRD2AKT1 | |
| SCHEMBL7675867 | 0.69 | ALDH1A1 (0.52) | MAPK8 | |
| SCHEMBL6949036 | 0.69 | MEN1 (0.53) | GPR132HTR1ADRD2LMNA | |
| SCHEMBL25876495 | 0.68 | TDP1 (0.51) | HTR1AMAPK8LMNA | |
| SCHEMBL7370595 | 0.68 | MAPK8 (0.50) | MAPK8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |