Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 13/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.35 |
| ▸ | TPH1 | P17752 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681015 | 0.91 | L3MBTL1 (0.39) | KIF11TRPV4TPH1MAPTALDH1A1 | |
| SCHEMBL7680485 | 0.66 | GPR119 (0.43) | TPH1MAPTALDH1A1 | |
| SCHEMBL7680493 | 0.64 | GPR119 (0.42) | TPH1MAPTALDH1A1 | |
| SCHEMBL7228470 | 0.64 | TRPV4 (0.35) | TRPV4MAPT | |
| SCHEMBL7686709 | 0.63 | CYP11B1 (0.36) | — | |
| Trifluoroacetic Acid SCHEMBL7227919 | 0.61 | FNTA (0.34) | TRPV4 | |
| SCHEMBL3569646 | 0.61 | KIF11 (0.81) | KIF11MAPT | |
| SCHEMBL20743638 | 0.59 | PKM (0.54) | TRPV4MAPTALDH1A1 | |
| SCHEMBL30309628 | 0.59 | PKM (0.54) | TRPV4MAPTALDH1A1 | |
| SCHEMBL7220418 | 0.59 | ALDH1A1 (0.40) | TRPV4LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350755-B1 | PEPTIDOMIMETIC COMPOUNDS THAT DO NOT HAVE A THIOL MOIETY; THERAPY OF ARTERIOSCLEROSIS AND DIABETIC VASCULAR PATHOLOGIES; | MERCK & CO., INC. | 2002-02-26 | — | — | US | disclosed |
| WO-2001051128-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-07-19 | — | — | WO | disclosed |