SCHEMBL7687809

SCHEMBL7687809

Cc1c(-c2cc(O)c(Cl)cc2F)nn(C)c1C#N

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AR P10275 3/20 0.33
RORC P51449 1/20 0.31
PDE10A Q9Y233 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7811612 0.88 AR (0.34) ARPDE10A
SCHEMBL7693284 0.88 AR (0.33) AR
SCHEMBL7686737 0.85 PDE10A (0.30) PDE10A
SCHEMBL7688339 0.85 LMNA (0.32) PDE10A
SCHEMBL7694533 0.83 NTRK1 (0.35) RORC
SCHEMBL7690601 0.82 HSP90AB1 (0.39) PDE10A
SCHEMBL7968440 0.82
SCHEMBL7690605 0.79 HSD11B1 (0.39)
SCHEMBL8022013 0.78 POLB (0.32) RORC
SCHEMBL7692799 0.77 PGK1 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6339046-B1 FOR CONTROLLING WEEDS SYNGENTA INVESTMENT CORPORATION 2002-01-15 US disclosed
EP-0839808-A1 Pyrazole derivatives, processes for their preparation, and their use as herbicides Novartis AG (CH) 1998-05-06 EP disclosed