Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.52 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 2/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL766796 | 0.88 | TRPV1 (0.68) | TRPV1KCNH2MLYCDMAPT | |
| SCHEMBL768664 | 0.85 | TRPV1 (0.55) | TRPV1KCNH2RAB9AALDH1A1MEN1 | |
| SCHEMBL768606 | 0.82 | TARBP2 (0.50) | TARBP2RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL31587044 | 0.74 | ADORA3 (0.50) | TARBP2RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL766776 | 0.72 | TRPV1 (0.75) | TRPV1KCNH2 | |
| SCHEMBL766813 | 0.71 | TRPV1 (0.62) | TRPV1MLYCDMEN1MAPTKMT2A | |
| SCHEMBL766505 | 0.70 | MLYCD (0.52) | TRPV1MLYCDMEN1MAPTKMT2A | |
| SCHEMBL13256885 | 0.70 | MLYCD (0.52) | TRPV1MLYCDMEN1MAPTKMT2A | |
| SCHEMBL766592 | 0.70 | TRPV1 (0.73) | TRPV1KCNH2 | |
| SCHEMBL766721 | 0.70 | TRPV1 (0.80) | TRPV1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, TRPV3 | TRPV1 1/4885TARBP2 3588/4885KCNH2 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.