Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARBP2 | Q15633 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 2/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL766505 | 0.87 | MLYCD (0.52) | MLYCDKDM4EMEN1MAPTKMT2A | |
| SCHEMBL768815 | 0.82 | TRPV1 (0.52) | TARBP2CYP1A2CYP2C9CYP2C19TDP2 | |
| SCHEMBL766700 | 0.80 | TRPV1 (0.54) | TARBP2TDP2MLYCDALDH1A1HTT | |
| SCHEMBL31587044 | 0.78 | ADORA3 (0.50) | TARBP2CYP1A2CYP2C9CYP2C19TDP2 | |
| SCHEMBL1686235 | 0.76 | TARBP2 (0.56) | TARBP2CYP1A2CYP2C9CYP2C19TDP2 | |
| SCHEMBL766813 | 0.75 | TRPV1 (0.62) | MLYCDKDM4EMEN1MAPTKMT2A | |
| SCHEMBL13256885 | 0.74 | MLYCD (0.52) | MLYCDKDM4EMEN1MAPTKMT2A | |
| SCHEMBL1686445 | 0.74 | TARBP2 (0.54) | TARBP2ALDH1A1PKMKDM4EPOLB | |
| SCHEMBL1686239 | 0.74 | TRPV1 (0.52) | TARBP2TDP2MLYCDALDH1A1PKM | |
| SCHEMBL18597734 | 0.74 | RAB9A (0.38) | ALDH1A1HTTKDM4EPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, TRPV3 | TARBP2 3588/4885CYP1A2 1322/4885CYP2C9 1170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.