Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.47 |
| ▸ | POLB | P06746 | 12/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.42 |
| ▸ | RECQL | P46063 | 5/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.40 |
| ▸ | PKM | P14618 | 10/20 | 0.39 |
| ▸ | TSHR | P16473 | 8/20 | 0.39 |
| ▸ | MEN1 | O00255 | 7/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 5/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7686913 | 0.81 | LMNA (0.48) | MAPTKMT2ANPSR1ALDH1A1PKM | |
| SCHEMBL7687762 | 0.80 | POLB (0.50) | MAPTPOLBTDP1KMT2ANPSR1 | |
| SCHEMBL7687262 | 0.77 | ALPL (0.43) | MAPTPOLBTDP1KMT2ANPSR1 | |
| SCHEMBL7690067 | 0.77 | MAP1LC3B (0.38) | MAPTKMT2AL3MBTL1ALDH1A1PKM | |
| SCHEMBL7689655 | 0.77 | MAP1LC3B (0.43) | LMNAMAP1LC3B | |
| Hydrochloric Acid SCHEMBL7682882 | 0.73 | KMT2A (0.33) | MAPTPOLBTDP1KMT2ANPSR1 | |
| SCHEMBL7680946 | 0.69 | HTR2C (0.40) | MAPTLMNA | |
| SCHEMBL1177395 | 0.65 | POLB (1.00) | MAPTPOLBTDP1KMT2ANPSR1 | |
| SCHEMBL7689218 | 0.64 | ALDH1A1 (0.55) | MAPTPOLBTDP1KMT2ANPSR1 | |
| SCHEMBL1177894 | 0.62 | POLB (0.62) | MAPTPOLBTDP1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |