Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.63 |
| ▸ | HTR7 | P34969 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108057 | 0.98 | HTR1A (0.61) | HTR1AHTR7MAPTKCNH2DRD2 | |
| SCHEMBL7689917 | 0.87 | MAPT (0.73) | HTR1AHTR7MAPTKCNH2DRD2 | |
| SCHEMBL8109562 | 0.87 | DRD2 (0.58) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL7689812 | 0.85 | MAPT (0.73) | HTR1AHTR7MAPTKCNH2DRD2 | |
| SCHEMBL7683387 | 0.80 | MAPT (0.72) | HTR1AHTR7MAPTKCNH2DRD2 | |
| SCHEMBL8103432 | 0.79 | HTR1A (0.64) | HTR1AHTR7DRD2HTR2ASIGMAR1 | |
| SCHEMBL7685556 | 0.79 | KCNH2 (0.64) | HTR1AHTR7KCNH2DRD2HTR2A | |
| SCHEMBL7689489 | 0.77 | KCNH2 (0.61) | HTR1AHTR7MAPTKCNH2DRD2 | |
| SCHEMBL4525555 | 0.75 | KCNH2 (1.00) | HTR1AHTR7KCNH2DRD2HTR2A | |
| SCHEMBL8406983 | 0.74 | HTR1A (0.77) | HTR1AHTR7KCNH2DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057820-A1 | Arylpiperazinylalkyl-3(2H)-pyridazinones as serotonin 5HT and dopamine D2 receptor agonists | FAES, Fabrica Espanola de Productos Quimicos y Farmaceuticos, S.A. (ES) | 2000-12-06 | — | — | EP | claimed |