SCHEMBL769320

SCHEMBL769320

O=S(=O)(O)c1ccccc1-c1ccc(Cl)cc1Cl

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 2/20 0.46
ITGA1 P56199 3/20 0.43
FLT1 P17948 2/20 0.43
FLT4 P35916 2/20 0.43
KDR P35968 2/20 0.43
PTGES2 Q9H7Z7 1/20 0.41
PTPN1 P18031 1/20 0.41
EDNRB P24530 1/20 0.39
EDNRA P25101 1/20 0.39
HSD11B1 P28845 1/20 0.39
AHR P35869 1/20 0.39
HSP90AA1 P07900 1/20 0.39
HSP90AB1 P08238 1/20 0.39
MAPT P10636 2/20 0.38
PGAM1 P18669 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CRHR1 P34998 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29365345 1.00 S100A4 (0.46) S100A4ITGA1FLT1FLT4KDR
SCHEMBL9487725 0.83 S100A4 (0.43) S100A4FLT1FLT4KDRHSD11B1
SCHEMBL4630192 0.82 PTPRC (0.43) HSD11B1HSP90AA1HSP90AB1PGAM1ALDH1A1
SCHEMBL196568 0.79 S100A4 (0.48) S100A4HSP90AA1ALDH1A1
SCHEMBL10574933 0.79 F2RL3 (0.42) FLT1FLT4KDRHSD11B1ALDH1A1
SCHEMBL458284 0.79 SMN1; SMN2 (0.48) S100A4MAPTPGAM1CYP2C9KDM4E
SCHEMBL3695968 0.77 S100A4 (0.46) S100A4HSP90AA1ALDH1A1
SCHEMBL3696775 0.77 S100A4 (0.46) S100A4HSP90AA1ALDH1A1
SCHEMBL3699050 0.77 S100A4 (0.46) S100A4HSP90AA1ALDH1A1
SCHEMBL4301050 0.77 S100A4 (0.46) S100A4HSP90AA1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025103215-A1 FOUR-MEMBERED-RING AMIDE COMPOUNDS AND USE THEREOF 青岛清原化合物有限公司 2025-05-22 WO disclosed
WO-2025067191-A1 FOUR-MEMBERED RING AMIDE COMPOUND AND USE THEREOF 青岛清原化合物有限公司 2025-04-03 WO disclosed
WO-2025056007-A1 FOUR-MEMBERED RING AMIDE COMPOUNDS AND USE THEREOF 青岛清原化合物有限公司 2025-03-20 WO disclosed
WO-2025051203-A1 FOUR-MEMBERED CYCLIC AMIDE COMPOUND AND USE THEREOF 青岛清原化合物有限公司 2025-03-13 WO disclosed
WO-2025026292-A1 4-MEMBERED CYCLIC AMIDE COMPOUND AND USE THEREOF 青岛清原化合物有限公司 2025-02-06 WO disclosed
CN-111406055-B Microbiocidal thiazole derivatives 先正达参股股份有限公司 2023-09-22 CN disclosed
CN-116783193-A Pesticidally active heterocyclic derivatives with sulfur containing substituents 先正达农作物保护股份公司 2023-09-19 CN disclosed
CN-110891949-B Pesticidally active heterocyclic derivatives with sulfur containing substituents 先正达参股股份有限公司 2023-05-23 CN disclosed
CN-109311830-B Microbicidal oxadiazole derivatives 先正达参股股份有限公司 2023-02-24 CN disclosed
CN-115244036-A Pesticidally active diazine-bisamide compounds 先正达农作物保护股份公司 2022-10-25 CN disclosed
CN-110891949-A Pesticidally active heterocyclic derivatives with sulphur containing substituents 先正达参股股份有限公司 2020-03-17 CN disclosed
CN-110730779-A Pesticidally active heterocyclic derivatives with sulphur containing substituents 先正达参股股份有限公司 2020-01-24 CN disclosed
CN-110612301-A Imidazopyrimidine derivatives with sulfur-containing phenyl and pyridyl substituents 先正达参股股份有限公司 2019-12-24 CN disclosed
CN-109153657-A Microbicidal oxadiazole derivatives 先正达参股股份有限公司 2019-01-04 CN disclosed
CN-108430980-A Microbicidal oxadiazole derivatives 先正达参股股份有限公司 2018-08-21 CN disclosed
US-8574607-B2 Spiroheterocyclic thiofuran dione derivatives SYNGENTA CROP PROTECTION, INC. (US) 2013-11-05 US disclosed
US-20120071319-A1 SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES SYNGENTA CROP PROTECTION, LLC (US) 2012-03-22 US disclosed
US-4058604-A OR ACARICIDALLY ACTIVE SUBSTANCES CIBA-GEIGY AG (CH) 1977-11-15 US disclosed
US-3980799-A OR ACARICIDALLY ACTIVE SUBSTANCES CIBA-GEIGY AG (CH) 1976-09-14 US disclosed
US-3940412-A 2,4,5-Trichloro- and 2,4,5-tribromoimidazole derivatives and pesticidal compositions containing them CIBA-GEIGY AG (CH) 1976-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120071319-A1 SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES DDT, DHFR, CYP1A1 S100A4 4145/4885ITGA1 1760/4885FLT1 4666/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.