Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 2/20 | 0.33 |
| ▸ | STAT5B | P51692 | 1/20 | 0.33 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.33 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5711934 | 0.87 | KDM5A (0.37) | EPHX1CTSSCTSKALOX5HTR2C | |
| SCHEMBL15800367 | 0.85 | CHRNB2 (0.36) | ALDH1A1ATMKMT2A | |
| SCHEMBL13546948 | 0.84 | CPN1 (0.37) | EPHX1SLC6A4LMNAKMT2A | |
| SCHEMBL9306400 | 0.79 | ALOX5 (0.55) | EPHX1CTSSCTSKALOX5GAA | |
| SCHEMBL21574018 | 0.78 | HTR2C (0.42) | EPHX1CTSSCTSKALOX5GAA | |
| SCHEMBL8911411 | 0.78 | HTR2C (0.42) | EPHX1CTSSCTSKALOX5GAA | |
| SCHEMBL7329124 | 0.76 | ALOX5 (0.43) | EPHX1CTSSCTSKALOX5GAA | |
| SCHEMBL6680983 | 0.76 | CTSK (0.37) | EPHX1CTSSCTSKALOX5GAA | |
| SCHEMBL4780561 | 0.75 | ALOX5 (0.39) | EPHX1CTSSCTSKALOX5GAA | |
| SCHEMBL2810316 | 0.74 | CTSS (0.35) | EPHX1CTSSCTSKALOX5HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355665-B1 | ANTIHISTAMINES, ANTIALLERGENS AND IRRITABLE BOWEL SYNDROME. | JAMES BLACK FOUNDATION LIMITED (GB) | 2002-03-12 | — | — | US | disclosed |
| WO-1999005114-A2 | 1H-4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-02-04 | — | — | WO | disclosed |