Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141823 | 0.86 | MMP8 (0.35) | HDAC1HDAC2ABL1 | |
| SCHEMBL7145400 | 0.71 | HDAC2 (0.43) | HDAC1HDAC2ABL1HDAC3 | |
| SCHEMBL25214665 | 0.70 | ABCC1 (0.55) | MAPTALDH1A1L3MBTL1MAPK1TDP1 | |
| SCHEMBL4457378 | 0.68 | THRB (0.43) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL6166846 | 0.68 | MAPT (0.59) | MAPTALDH1A1L3MBTL1MAPK1TDP1 | |
| SCHEMBL7139674 | 0.68 | ALDH1A1 (0.44) | MAPTMEN1KMT2AALDH1A1HTT | |
| SCHEMBL29805778 | 0.67 | KMT2A (0.52) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL7703580 | 0.67 | HCAR3 (0.38) | MAPTMEN1KMT2AALDH1A1HDAC1 | |
| SCHEMBL7698568 | 0.67 | ALDH1A1 (0.43) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL7698560 | 0.67 | DHODH (0.38) | MAPTMEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |