Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAMP1 | O60894 | 6/20 | 0.35 |
| ▸ | CALCRL | Q16602 | 6/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7704830 | 0.86 | HSD11B1 (0.35) | HSD11B1KDM1A | |
| SCHEMBL7704973 | 0.82 | RAMP1 (0.35) | RAMP1CALCRLP2RX3P2RX2HSD11B1 | |
| SCHEMBL7708206 | 0.78 | PARP1 (0.42) | P2RX3P2RX2SMN1; SMN2 | |
| SCHEMBL7704910 | 0.78 | HDAC1 (0.45) | SMN1; SMN2 | |
| SCHEMBL7704884 | 0.77 | P2RX3 (0.40) | RAMP1CALCRLP2RX3P2RX2SMN1; SMN2 | |
| SCHEMBL7000559 | 0.75 | HDAC1 (0.33) | — | |
| SCHEMBL7708189 | 0.75 | HDAC3 (0.37) | SMN1; SMN2 | |
| SCHEMBL7711366 | 0.75 | HDAC1 (0.37) | SMN1; SMN2 | |
| SCHEMBL7710867 | 0.74 | ALDH1A1 (0.38) | SMN1; SMN2 | |
| SCHEMBL7704988 | 0.74 | HDAC3 (0.36) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |