Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7711197 | 0.91 | MKNK1 (0.37) | MKNK1MKNK2BACE1FPR2 | |
| SCHEMBL7709564 | 0.88 | MKNK1 (0.41) | MKNK1MKNK2BACE1 | |
| SCHEMBL7710836 | 0.84 | ERN1 (0.35) | — | |
| SCHEMBL7709563 | 0.82 | MKNK1 (0.35) | MKNK1MKNK2APPBACE1 | |
| SCHEMBL7705399 | 0.80 | BACE1 (0.35) | BACE1 | |
| SCHEMBL7711538 | 0.79 | MKNK1 (0.33) | MKNK1MKNK2APPBACE1PTGES | |
| SCHEMBL7706611 | 0.76 | MKNK1 (0.39) | MKNK1MKNK2BACE1 | |
| SCHEMBL7712995 | 0.75 | BACE1 (0.41) | BACE1 | |
| SCHEMBL7708820 | 0.73 | BACE1 (0.33) | BACE1 | |
| SCHEMBL7708344 | 0.72 | ERN1 (0.32) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |