Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7711537 | 0.90 | — | — | |
| SCHEMBL7705214 | 0.84 | TYR (0.30) | — | |
| SCHEMBL7705125 | 0.79 | MKNK1 (0.32) | MKNK1MKNK2APPBACE1PTGES | |
| SCHEMBL7708820 | 0.78 | BACE1 (0.33) | BACE1 | |
| SCHEMBL7715200 | 0.76 | MKNK1 (0.37) | MKNK1MKNK2BACE1 | |
| SCHEMBL7706611 | 0.74 | MKNK1 (0.39) | MKNK1MKNK2BACE1 | |
| SCHEMBL7712995 | 0.73 | BACE1 (0.41) | BACE1 | |
| SCHEMBL7710613 | 0.73 | CYP11B1 (0.38) | MKNK1MKNK2BACE1 | |
| SCHEMBL882893 | 0.72 | BACE1 (0.36) | MKNK1MKNK2APPBACE1DYRK1A | |
| SCHEMBL7710882 | 0.71 | CCNC (0.38) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |