Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 4/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 2/20 | 0.30 |
| ▸ | F2R | P25116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7706611 | 0.88 | MKNK1 (0.39) | MKNK1MKNK2BACE1CYP11B1CYP11B2 | |
| SCHEMBL7711538 | 0.86 | MKNK1 (0.33) | MKNK1MKNK2BACE1APP | |
| SCHEMBL7708820 | 0.84 | BACE1 (0.33) | BACE1CYP11B1CYP11B2CTSD | |
| SCHEMBL7705125 | 0.82 | MKNK1 (0.32) | MKNK1MKNK2BACE1APP | |
| SCHEMBL7713517 | 0.77 | CTSD (0.32) | BACE1CTSD | |
| SCHEMBL7715200 | 0.77 | MKNK1 (0.37) | MKNK1MKNK2BACE1CYP11B1CYP11B2 | |
| SCHEMBL7712995 | 0.76 | BACE1 (0.41) | BACE1CYP11B1CYP11B2CTSD | |
| SCHEMBL7711537 | 0.74 | — | — | |
| SCHEMBL882893 | 0.74 | BACE1 (0.36) | MKNK1MKNK2BACE1APPCTSD | |
| SCHEMBL7710613 | 0.72 | CYP11B1 (0.38) | MKNK1MKNK2BACE1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |