Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 4/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7704729 | 0.89 | MKNK1 (0.39) | MKNK1MKNK2CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL7709563 | 0.88 | MKNK1 (0.35) | MKNK1MKNK2CYP11B1CYP11B2BACE1 | |
| SCHEMBL7711197 | 0.85 | MKNK1 (0.37) | MKNK1MKNK2CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL7712995 | 0.84 | BACE1 (0.41) | CYP11B1CYP11B2CYP1A2CYP3A4BACE1 | |
| SCHEMBL7710882 | 0.81 | CCNC (0.38) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7705408 | 0.78 | BACE1 (0.35) | BACE1KCNH2 | |
| SCHEMBL7708344 | 0.77 | ERN1 (0.32) | BACE1KCNH2 | |
| SCHEMBL7705125 | 0.76 | MKNK1 (0.32) | MKNK1MKNK2BACE1 | |
| SCHEMBL7715200 | 0.75 | MKNK1 (0.37) | MKNK1MKNK2CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL7705409 | 0.75 | BACE1 (0.45) | BACE1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |