Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | GBA2 | Q9HCG7 | 5/20 | 0.39 |
| ▸ | GLB1 | P16278 | 1/20 | 0.39 |
| ▸ | UGCG | Q16739 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7706522 | 1.00 | GBA1 (0.46) | GBA1BCHEHTR1ADRD2DRD1 | |
| SCHEMBL7703115 | 0.82 | GBA1 (0.63) | GBA1GBA2GLB1UGCG | |
| SCHEMBL7703107 | 0.82 | GBA1 (0.63) | GBA1GBA2GLB1UGCG | |
| SCHEMBL13748363 | 0.76 | GBA1 (0.38) | GBA1 | |
| SCHEMBL8518882 | 0.73 | GNAO1 (0.46) | GBA1BCHEHTR1ADRD2DRD1 | |
| SCHEMBL14749169 | 0.73 | GNAI3 (0.42) | HTR1ADRD2DRD1DRD4DRD5 | |
| SCHEMBL14749186 | 0.73 | GNAI3 (0.42) | HTR1ADRD2DRD1DRD4DRD5 | |
| SCHEMBL12912029 | 0.73 | GNAI3 (0.42) | HTR1ADRD2DRD1DRD4DRD5 | |
| SCHEMBL12367023 | 0.71 | OPRK1 (0.31) | GBA1 | |
| SCHEMBL4473375 | 0.71 | GLB1 (0.53) | GBA1BCHEHTR1ADRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880500-B1 | ESTERS OF 3-HYDROXY-PIPERIDINEMETHANOL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2002-07-31 | — | — | EP | disclosed |
| US-6096761-A | REACTING A N-SUBSTITUTED 4-METHANOL-3-HYDROXY OR ALKOXY-PIPERIDINE INTERMEDIATE WITH A CARBOXYLIC ACID DERIVATIVES; ADMINISTERING TO AN ANIMAL SUFFERING WITH A CONDITION RELATED TO HAMPERED OR IMPAIRED GASTRIC EMPTYING | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-08-01 | — | — | US | disclosed |
| EP-0880500-A1 | ESTERS OF 3-HYDROXY-PIPERIDINEMETHANOL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030031-A1 | ESTERS OF 3-HYDROXY-PIPERIDINEMETHANOL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-08-21 | — | — | WO | disclosed |