SCHEMBL7707702

SCHEMBL7707702

Cn1nc(-c2ccc(Cl)cc2F)cc1Cl

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KMO O15229 2/20 0.42
HSD11B1 P28845 3/20 0.42
EGLN2 Q96KS0 1/20 0.38
TRPM5 Q9NZQ8 1/20 0.38
GRM2 Q14416 7/20 0.36
CYP2C9 P11712 1/20 0.36
GRIN2B Q13224 1/20 0.36
BCHE P06276 1/20 0.36
PDE2A O00408 1/20 0.35
CYP1B1 Q16678 1/20 0.34
CRHR1 P34998 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6319050 0.84 KMO (0.43) KMOHSD11B1EGLN2GRM2CYP2C9
SCHEMBL9081963 0.84 KMO (0.40) KMOHSD11B1EGLN2TRPM5GRM2
SCHEMBL7508249 0.81 KMO (0.39) KMOHSD11B1EGLN2TRPM5GRM2
SCHEMBL6320670 0.78 KMO (0.36) KMOHSD11B1EGLN2GRM2CYP2C9
SCHEMBL7475083 0.76 CA12 (0.48) KMOGRIN2B
SCHEMBL14694258 0.73 MAPT (0.49)
SCHEMBL2344409 0.73 PDE7A (0.38) HSD11B1CYP2C9
SCHEMBL26096641 0.72 HSD11B1 (0.44) KMOHSD11B1EGLN2GRM2CYP2C9
SCHEMBL6311757 0.71 EGLN2 (0.43) KMOHSD11B1EGLN2GRM2BCHE
SCHEMBL16202038 0.71 KMO (0.46) KMOHSD11B1EGLN2GRM2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6365552-B1 AS HERBICIDE BASF AKTIENGESELLSCHAFT (DE) 2002-04-02 US disclosed
EP-0759907-B1 SUBSTITUTED 3-PHENYLPYRAZOLES FOR USE AS HERBICIDES BASF AG (DE) 2001-10-10 EP disclosed
US-5928999-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1999-07-27 US disclosed
US-5744426-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1998-04-28 US disclosed
CN-1152305-A Substituted 3-phenylpyrazoles as herbicides BASF AG (DE) 1997-06-18 CN disclosed
CN-1151159-A Substituted 3-phenylpyrazoles BASF AG (DE) 1997-06-04 CN disclosed
EP-0763025-A1 SUBSTITUTED 3-PHENYLPYRAZOLES AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1997-03-19 EP disclosed
WO-1996015115-A1 HERBICIDAL PYRAZOLE COMPOUNDS ZENECA LIMITED (GB) 1996-05-23 WO disclosed
WO-1995033728-A1 SUBSTITUTED 3-PHENYLPYRAZOLES AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1995-12-14 WO disclosed