Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.37 |
| ▸ | ASIC1 | P78348 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2342660 | 0.89 | PSEN1 (0.43) | PDE7AMEN1KMT2AATMPDE1A | |
| SCHEMBL8422328 | 0.75 | PTGS2 (0.65) | CYP2C9 | |
| SCHEMBL23149742 | 0.75 | AR (0.43) | ARPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15814002 | 0.74 | F2RL3 (0.42) | MEN1KMT2AF2RL3GABRG2GABRB3 | |
| SCHEMBL23149770 | 0.74 | AR (0.42) | ARPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7707702 | 0.73 | KMO (0.42) | CYP2C9HSD11B1 | |
| SCHEMBL8125675 | 0.73 | PTGS2 (0.65) | — | |
| SCHEMBL8424030 | 0.72 | ALOX5AP (0.40) | CYP3A4 | |
| SCHEMBL8424032 | 0.71 | PTGS2 (0.42) | — | |
| SCHEMBL6913488 | 0.71 | ALDH1A1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8377953-B2 | Isothiazole and pyrazole derivatives as fungicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-8377953-B2 | Isothiazole and pyrazole derivatives as fungicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-8377953-B2 | Isothiazole and pyrazole derivatives as fungicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-20110301034-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA CROP PROTECTION LLC (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301034-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA CROP PROTECTION LLC (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301034-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA CROP PROTECTION LLC (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110224241-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2011-09-15 | — | — | US | disclosed |
| US-20110224241-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2011-09-15 | — | — | US | disclosed |
| US-20110224241-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2011-09-15 | — | — | US | disclosed |
| EP-2358699-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | Syngenta Participations AG (CH) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010069877-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-06-24 | — | — | WO | disclosed |
| WO-2010069877-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-06-24 | — | — | WO | disclosed |
| EP-2162448-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES | Syngeta Participations AG (CH) | 2010-03-17 | — | — | EP | disclosed |
| WO-2009007098-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007098-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224241-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES | NOX3, CBR3, NOS3 | PDE7A 3636/4885MEN1 968/4885KMT2A 2947/4885 |
| US-20110301034-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | ING2, IGFBP1, IP6K1 | PDE7A 4392/4885MEN1 4418/4885KMT2A 2213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.