Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 4/20 | 0.44 |
| ▸ | PPARA | Q07869 | 4/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551585 | 0.91 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAPDE3BPDE3APPARG | |
| SCHEMBL8554409 | 0.89 | LMNA (0.47) | SMN1; SMN2LMNAPDE3BPDE3APPARG | |
| SCHEMBL8553605 | 0.82 | ALOX5 (0.48) | SMN1; SMN2LMNAPDE3BPDE3APPARG | |
| SCHEMBL251645 | 0.82 | ALOX5 (0.43) | SMN1; SMN2LMNAPDE3BPDE3APPARG | |
| SCHEMBL8551933 | 0.81 | PDE3B (0.51) | SMN1; SMN2LMNAPDE3BPDE3APPARG | |
| SCHEMBL7424550 | 0.79 | ALOX5 (0.39) | SMN1; SMN2LMNAPDE3BPDE3AALOX5 | |
| SCHEMBL8551838 | 0.78 | LMNA (0.55) | SMN1; SMN2LMNAPDE3BPDE3APPARG | |
| SCHEMBL8557469 | 0.78 | PDE3B (0.52) | SMN1; SMN2LMNAPDE3BPDE3APPARG | |
| SCHEMBL8554263 | 0.78 | ALOX5 (0.39) | SMN1; SMN2LMNAPDE3BPDE3AALOX5 | |
| SCHEMBL8551861 | 0.78 | ALOX5 (0.41) | SMN1; SMN2LMNAPDE3BPDE3AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |