Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PNP | P00491 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | HAT1 | O14929 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8627726 | 0.99 | ALOX5 (0.40) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL6930961 | 0.88 | ALOX5 (0.39) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL8556676 | 0.86 | ALOX5 (0.38) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL8555972 | 0.80 | ALOX5 (0.37) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL251645 | 0.76 | ALOX5 (0.43) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL8554263 | 0.76 | ALOX5 (0.39) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL8551585 | 0.74 | SMN1; SMN2 (0.48) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL8551861 | 0.73 | ALOX5 (0.41) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL8555588 | 0.73 | SMN1; SMN2 (0.47) | ALOX5LMNASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL7707708 | 0.73 | KMT2A (0.41) | LMNASMN1; SMN2PDE3BPDE3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |