Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 14/20 | 0.42 |
| ▸ | EDNRB | P24530 | 11/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424082 | 0.85 | SLC22A12 (0.42) | SLC22A12CA12CA1CA2CA9 | |
| SCHEMBL7422706 | 0.78 | SLC22A12 (0.41) | SLC22A12EDNRAEDNRBALDH1A1MAPK1 | |
| SCHEMBL7426853 | 0.77 | SLC22A12 (0.40) | SLC22A12CA12CA1CA2CA9 | |
| SCHEMBL7423537 | 0.75 | MEN1 (0.40) | SLC22A12EDNRAALDH1A1MAPK1LMNA | |
| SCHEMBL7473906 | 0.74 | ALDH1A1 (0.43) | SLC22A12EDNRAEDNRBALDH1A1MAPK1 | |
| SCHEMBL7707720 | 0.72 | FABP4 (0.48) | SLC22A12EDNRAEDNRBALDH1A1MAPK1 | |
| SCHEMBL7426960 | 0.72 | ALDH1A1 (0.51) | SLC22A12EDNRAEDNRBALDH1A1MAPK1 | |
| SCHEMBL7425503 | 0.70 | EDNRA (0.41) | SLC22A12EDNRAEDNRBALDH1A1MAPK1 | |
| SCHEMBL7418953 | 0.70 | EDNRA (0.39) | SLC22A12EDNRAEDNRBALDH1A1 | |
| SCHEMBL7419529 | 0.70 | TP53 (0.49) | SLC22A12MAPK8ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |