Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 7/20 | 1.00 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708524 | 0.85 | HCRTR2 (0.74) | HCRTR2HCRTR1LMNATP53TSPO | |
| SCHEMBL7710901 | 0.79 | HCRTR2 (1.00) | HCRTR2HCRTR1KMT2AMAPTLMNA | |
| SCHEMBL2594714 | 0.79 | HCRTR2 (0.64) | HCRTR2HCRTR1KMT2AMAPTLMNA | |
| SCHEMBL7706361 | 0.77 | HCRTR2 (0.62) | HCRTR2HCRTR1KMT2AMAPTLMNA | |
| SCHEMBL7709453 | 0.77 | HCRTR2 (1.00) | HCRTR2HCRTR1KMT2AMAPTLMNA | |
| SCHEMBL7701854 | 0.73 | HCRTR2 (0.86) | HCRTR2HCRTR1KMT2AMAPTLMNA | |
| SCHEMBL7707423 | 0.72 | HCRTR2 (1.00) | HCRTR2HCRTR1KMT2AMAPTALDH1A1 | |
| SCHEMBL14102410 | 0.71 | RAB9A (0.62) | HCRTR2HCRTR1KMT2AMAPTLMNA | |
| SCHEMBL7709056 | 0.71 | HCRTR2 (0.82) | HCRTR2HCRTR1KMT2AMAPTLMNA | |
| SCHEMBL2594733 | 0.70 | HCRTR1 (0.96) | HCRTR2HCRTR1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |