Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.56 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16002483 | 0.79 | GPR119 (0.47) | GPR119PTPN2PTPN1PTPN6JAK2 | |
| SCHEMBL5705188 | 0.76 | ALDH1A1 (0.48) | GPR119JAK2JAK1ALDH1A1 | |
| SCHEMBL5705189 | 0.76 | ALDH1A1 (0.48) | GPR119JAK2JAK1ALDH1A1 | |
| SCHEMBL7710704 | 0.76 | GPR119 (0.56) | GPR119PTPN2PTPN1PTPN6KDM4E | |
| SCHEMBL29960495 | 0.76 | GPR119 (0.50) | GPR119PTPN2PTPN1PTPN6JAK2 | |
| SCHEMBL2256940 | 0.76 | SIGMAR1 (0.39) | — | |
| SCHEMBL6490546 | 0.74 | GPR119 (0.48) | GPR119JAK2JAK1KDM4EPKM | |
| SCHEMBL15834287 | 0.74 | GPR119 (0.56) | GPR119KDM4EPKMNAMPT | |
| SCHEMBL14039529 | 0.74 | GPR119 (0.53) | GPR119JAK2JAK1KDM4EPKM | |
| SCHEMBL3436365 | 0.73 | GPR119 (0.58) | GPR119PTPN2PTPN1PTPN6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380891-A1 | Substituted piperidino-dihydrothienopyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-26 | — | — | EP | disclosed |
| WO-2011124525-A1 | COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4 INHIBITORS AND EP4 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-13 | — | — | WO | disclosed |