SCHEMBL7713013

SCHEMBL7713013

O=C1NC(=O)N(COCCO)C(=O)C1[Se]c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
UPP1 Q16831 1/20 0.37
ALDH1A1 P00352 2/20 0.34
TSHR P16473 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
RECQL P46063 1/20 0.31
ADK P55263 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5831498 0.76 EP300 (0.43) UPP1ALDH1A1
SCHEMBL3950895 0.65 ALDH1A1 (0.40) ALDH1A1TSHR
SCHEMBL8952213 0.61 MMP9 (0.39) UPP1ALDH1A1RECQL
SCHEMBL8267450 0.61 MGLL (0.50) UPP1ALDH1A1TSHRRECQL
SCHEMBL9178077 0.59 MEN1 (0.41) UPP1ALDH1A1TSHRTDP1L3MBTL1
SCHEMBL9357957 0.59 LMNA (0.40) ALDH1A1TSHR
SCHEMBL9697471 0.58 EHMT2 (0.42) UPP1ALDH1A1TSHRTDP1RECQL
SCHEMBL18254504 0.57 EP300 (0.49) ALDH1A1
Phthalimide SCHEMBL4446059 0.57 GSK3B (0.60) TSHR
Phthalimide SCHEMBL3251016 0.56 GSK3B (0.58) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0725641-B1 NOVEL INHIBITORS OF URIDINE PHOSPHORYLASE (UrdPase) AND DIHYDROURACIL DEHYDROGENASE (DHUDase) EL KOUNI MAHMOUD H (US) 2000-12-13 EP claimed
US-5721241-A PYRIMIDINE COMPOUND USEFUL TO DISRUPT VIRAL, CANCER, FUNGAL, PARASITE OR BACTERIAL REPLICATION AND DIHYDROURACIL DEHYDROGENASE OR URIDINE PHOSPHORYLASE INHIBITORS el Kouni, Mahmoud H. (US) 1998-02-24 US claimed
EP-0725641-A4 1996-09-04 EP claimed
EP-0725641-A1 NOVEL ENZYME INHIBITORS, THEIR SYNTHESIS, AND METHODS FOR USE El Kouni, Mahmoud H. (US) 1996-08-14 EP claimed
WO-1995012400-A1 NOVEL ENZYME INHIBITORS, THEIR SYNTHESIS, AND METHODS FOR USE UAB RESEARCH FOUNDATION (US) 1995-05-11 WO claimed
US-RE37623-E1 PHENYLTHIO AND PHENYLSELENO PYRIMIDINE ANALOGS el Kouni, Mahmoud H. 2002-04-02 US disclosed
EP-0725641-B1 NOVEL INHIBITORS OF URIDINE PHOSPHORYLASE (UrdPase) AND DIHYDROURACIL DEHYDROGENASE (DHUDase) EL KOUNI MAHMOUD H (US) 2000-12-13 EP disclosed
US-5721241-A PYRIMIDINE COMPOUND USEFUL TO DISRUPT VIRAL, CANCER, FUNGAL, PARASITE OR BACTERIAL REPLICATION AND DIHYDROURACIL DEHYDROGENASE OR URIDINE PHOSPHORYLASE INHIBITORS el Kouni, Mahmoud H. (US) 1998-02-24 US disclosed
US-5476855-A Pyrimidine analogs and nucleosides el Kouni, Mahmoud H. (US) 1995-12-19 US disclosed