Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.37 |
| ▸ | NCEH1 | Q6PIU2 | 3/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29954877 | 0.76 | GAA (0.46) | MEN1NPC1GAARAB9AKMT2A | |
| SCHEMBL487112 | 0.73 | TRPV1 (0.44) | MEN1NPC1RAB9AKMT2ANQO2 | |
| SCHEMBL7709280 | 0.72 | ALDH1A1 (0.39) | MEN1NPC1GAARAB9AKMT2A | |
| SCHEMBL2396852 | 0.71 | ALDH1A1 (0.63) | MEN1NPC1GAARAB9AKMT2A | |
| SCHEMBL24150678 | 0.71 | LMNA (0.46) | MEN1NPC1GAARAB9AKMT2A | |
| SCHEMBL30190664 | 0.71 | LMNA (0.46) | MEN1NPC1GAARAB9AKMT2A | |
| SCHEMBL7717601 | 0.71 | ALDH1A1 (0.37) | MEN1NPC1GAARAB9AKMT2A | |
| SCHEMBL5622577 | 0.70 | MEN1 (0.45) | MEN1NPC1GAARAB9AKMT2A | |
| SCHEMBL24151446 | 0.70 | AXL (0.37) | MEN1NPC1GAARAB9AKMT2A | |
| SCHEMBL14862206 | 0.70 | ALDH1A1 (0.42) | GAAKAT6ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |