Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7715893 | 0.86 | KCNQ2 (0.54) | KCNQ2SIGMAR1LMNA | |
| SCHEMBL7715909 | 0.83 | KCNQ2 (0.48) | KCNQ2SIGMAR1LMNAADRA1DADRA1A | |
| SCHEMBL8008253 | 0.82 | SIGMAR1 (0.52) | KCNQ2SIGMAR1DPP4ADRA1DADRA1A | |
| SCHEMBL8008257 | 0.82 | SIGMAR1 (0.52) | KCNQ2SIGMAR1DPP4ADRA1DADRA1A | |
| SCHEMBL8006026 | 0.82 | SIGMAR1 (0.51) | KCNQ2SIGMAR1CHRM4METAP2DPP4 | |
| SCHEMBL8005302 | 0.81 | KCNQ2 (0.47) | KCNQ2SIGMAR1CHRM4METAP2DPP4 | |
| SCHEMBL7844417 | 0.79 | KCNQ2 (0.46) | KCNQ2SIGMAR1CHRM4METAP2DPP4 | |
| SCHEMBL7714987 | 0.74 | KDM4E (0.44) | CHRM4DRD2DRD4DRD3 | |
| SCHEMBL7711219 | 0.74 | DRD2 (0.48) | CHRM4DRD2DRD4DRD3 | |
| SCHEMBL13651261 | 0.71 | ADRA1A (0.46) | ADRA1DADRA1AADRA1BCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376503-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC | 2002-04-23 | — | — | US | disclosed |