SCHEMBL7719928

SCHEMBL7719928

CC1CN(c2ccccc2)N=C1N

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 5/20 0.40
KDM4E B2RXH2 5/20 0.40
MAPK1 P28482 5/20 0.40
ALDH1A1 P00352 5/20 0.40
GAA P10253 4/20 0.40
MAPT P10636 4/20 0.40
GLA P06280 4/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
CASP3 P42574 1/20 0.40
RECQL P46063 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
G6PD P11413 1/20 0.40
TDP1 Q9NUW8 2/20 0.37
HPGD P15428 3/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
USP2 O75604 1/20 0.37
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7714586 0.82 PTGS2 (0.38) MAPK1ALDH1A1MAPTNPC1RAB9A
SCHEMBL10656600 0.82 ABL1 (0.58) L3MBTL1KDM4EMAPK1ALDH1A1GAA
SCHEMBL11063972 0.80 ALOX5 (0.42) L3MBTL1DHFRMEN1KMT2AALOX5
SCHEMBL908243 0.80 DHFR (0.43) KDM4EALDH1A1GAAMAPTNPC1
SCHEMBL11050112 0.78 ALDH1A1 (0.46) L3MBTL1KDM4EMAPK1ALDH1A1GAA
SCHEMBL972562 0.78 L3MBTL1 (0.43) L3MBTL1KDM4EMAPK1ALDH1A1GAA
SCHEMBL908501 0.76 MEN1 (0.42) KDM4EALDH1A1GAAMAPTGLA
SCHEMBL11091577 0.71 ABL1 (0.42) L3MBTL1KDM4EMAPK1ALDH1A1GAA
SCHEMBL8232057 0.71 MAPT (0.35) L3MBTL1KDM4EMAPK1ALDH1A1GAA
SCHEMBL10656731 0.69 ABL1 (0.66) L3MBTL1KDM4EMAPK1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6387136-B1 OXIDATION COLOR DYES AND COUPLER L'OREAL S.A. (FR) 2002-05-14 US claimed
EP-0974337-B1 Keratinous fibre dyeing compositions containing 3-amino pyrazoline derivatives as coupling agents, process for dyeing and dyeing kit OREAL (FR) 2001-03-21 EP claimed
EP-0974337-A1 Keratinous fibre dyeing compositions containing 3-amino pyrazoline derivatives as coupling agents, process for dyeing and dyeing kit L'OREAL (FR) 2000-01-26 EP claimed
US-6387136-B1 OXIDATION COLOR DYES AND COUPLER L'OREAL S.A. (FR) 2002-05-14 US disclosed
EP-0974337-B1 Keratinous fibre dyeing compositions containing 3-amino pyrazoline derivatives as coupling agents, process for dyeing and dyeing kit OREAL (FR) 2001-03-21 EP disclosed
EP-0974337-A1 Keratinous fibre dyeing compositions containing 3-amino pyrazoline derivatives as coupling agents, process for dyeing and dyeing kit L'OREAL (FR) 2000-01-26 EP disclosed
EP-0022578-B1 PHARMACEUTICAL COMPOSITIONS CONTAINING 3-AMINO-PYRAZOLINE DERIVATIVES THE WELLCOME FOUNDATION LIMITED (GB) 1988-06-29 EP disclosed
US-4556671-A Pharmaceutical formulations BURROUGHS WELLCOME CO. (US) 1985-12-03 US disclosed
US-4448973-A ANTIINFLAMMATORY, ANALGESIC AGENTS; BACTERICIDES, FUNGICIDES AMERICAN CYANAMID COMPANY (US) 1984-05-15 US disclosed
US-4447442-A ANTIINFLAMMATORY, ANTIARTHRITIC, ANTIHISTAMINE, ANTIALLERGENS, ANALGESICS, BACTERICIDES, AND FUNGICIDES AMERICAN CYANAMID COMPANY (US) 1984-05-08 US disclosed
US-4432991-A ANALGESICS, FUNGICIDE, BACTERICIDE, ANTIINFLAMMATORY, OR ANTIARTHRITIC AGENTS, ANTIALLERGENS, AND BRONCHODILATOR AMERICAN CYANAMID COMPANY (US) 1984-02-21 US disclosed
EP-0070376-A1 Heterocyclic substituted-amino-pyrazolines AMERICAN CYANAMID COMPANY (US) 1983-01-26 EP disclosed
US-4360680-A ANALGESIC, ANTIINFLAMMATORY AGENT, FUNGICIDE AND BACTERICIDE AMERICAN CYANAMID COMPANY (US) 1982-11-23 US disclosed
US-4348527-A ANALGESICS, BACTERICIDES, FUNGICIDES AMERICAN CYANAMID COMPANY (US) 1982-09-07 US disclosed
US-4268436-A OXIDATIVE DIAZOTIZATION WITH NITROSYLSULFURIC ACID, ALKALINE METAL NITRITES, OR ALKYL NITRITES AZIENDE COLORI NAZIONALI AFFINI ACNA S.P.A. (IT) 1981-05-19 US disclosed
EP-0022578-A1 Pharmaceutical compositions containing 3-Amino-pyrazoline derivatives THE WELLCOME FOUNDATION LIMITED (GB) 1981-01-21 EP disclosed
US-4149005-A Process for preparing 1-phenyl-3-aminopyrazoles MONTEDISON S.P.A. (IT) 1979-04-10 US disclosed