Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.44 |
| ▸ | PTGIR | P43119 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7720077 | 0.84 | CASP1 (0.48) | L3MBTL1GRIN1GRIN2BNPC1RAB9A | |
| SCHEMBL4054330 | 0.83 | MAPT (0.46) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7724970 | 0.82 | CRHR1 (0.49) | L3MBTL1NPC1RAB9ACRHR1NPBWR1 | |
| SCHEMBL7726552 | 0.80 | NPC1 (0.47) | L3MBTL1NPC1RAB9ACRHR1NPBWR1 | |
| SCHEMBL7723523 | 0.80 | CRHR1 (0.51) | L3MBTL1GRIN1GRIN2BNPC1RAB9A | |
| SCHEMBL7726527 | 0.80 | CRHR1 (0.45) | L3MBTL1GRIN1GRIN2BNPC1RAB9A | |
| SCHEMBL7724783 | 0.80 | L3MBTL1 (0.44) | L3MBTL1GRIN1GRIN2BNPC1RAB9A | |
| SCHEMBL7724779 | 0.79 | MAPT (0.53) | L3MBTL1NPC1RAB9ACRHR1PTGIR | |
| SCHEMBL7723691 | 0.78 | CRHR1 (0.49) | L3MBTL1GRIN1GRIN2BNPC1RAB9A | |
| SCHEMBL7726116 | 0.78 | ADORA2A (0.61) | L3MBTL1NPC1RAB9ANPBWR1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |