Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7730697 | 0.88 | SMN1; SMN2 (0.44) | TGM2MAPTMEN1KMT2AGAA | |
| SCHEMBL7728745 | 0.87 | MAPT (0.44) | TGM2MAPTMEN1KMT2APOLB | |
| SCHEMBL7734014 | 0.84 | GAA (0.40) | TGM2MAPTMEN1KMT2AGAA | |
| SCHEMBL7722097 | 0.83 | TGM2 (0.39) | TGM2MAPTMC4RLMNA | |
| SCHEMBL7727837 | 0.82 | SIGMAR1 (0.43) | HSD11B1 | |
| SCHEMBL7728662 | 0.79 | DPP4 (0.42) | TGM2MEN1KMT2AHSD11B1 | |
| SCHEMBL7730641 | 0.79 | NPBWR1 (0.39) | TGM2POLBLMNA | |
| SCHEMBL7722094 | 0.79 | GPR119 (0.36) | — | |
| SCHEMBL7722244 | 0.79 | GPR119 (0.36) | — | |
| SCHEMBL7730976 | 0.77 | MCL1 (0.44) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |