Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7722089 | 0.84 | TGM2 (0.42) | LMNATGM2TP53ADAM17ADAMTS5 | |
| SCHEMBL7728458 | 0.75 | DRD2 (0.51) | LMNATGM2TP53DRD2DRD3 | |
| SCHEMBL7728454 | 0.75 | DRD2 (0.51) | LMNATGM2TP53DRD2DRD3 | |
| SCHEMBL7727563 | 0.75 | HTRA1 (0.39) | HTRA1 | |
| SCHEMBL7729320 | 0.74 | MMP2 (0.37) | HTRA1 | |
| SCHEMBL7722003 | 0.74 | TGM2 (0.42) | LMNATGM2TP53DRD2DRD3 | |
| SCHEMBL7722009 | 0.74 | TGM2 (0.42) | LMNATGM2TP53DRD2DRD3 | |
| SCHEMBL7722007 | 0.74 | TGM2 (0.42) | LMNATGM2TP53DRD2DRD3 | |
| SCHEMBL7722097 | 0.74 | TGM2 (0.39) | LMNATGM2TP53ADAM17ADAMTS5 | |
| SCHEMBL29799597 | 0.71 | DRD2 (0.45) | TGM2DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |
| WO-2000001714-A1 | EFFLUX PUMP INHIBITORS | MICROCIDE PHARMACEUTICALS, INC. (US) | 2000-01-13 | — | — | WO | disclosed |