SCHEMBL772274

SCHEMBL772274

FC(F)(F)c1ccc(-c2ncc[nH]2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NISCH Q9Y2I1 3/20 0.58
MTOR P42345 1/20 0.57
ADK P55263 1/20 0.57
KDM4E B2RXH2 3/20 0.51
ALDH1A1 P00352 2/20 0.51
KIF11 P52732 2/20 0.50
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP19A1 P11511 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
GFER P55789 1/20 0.47
MRGPRX4 Q96LA9 1/20 0.47
SCN2A Q99250 2/20 0.46
PDE3B Q13370 1/20 0.46
PDE3A Q14432 1/20 0.46
TRPV1 Q8NER1 2/20 0.45
COMT P21964 1/20 0.45
FPR2 P25090 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL722191 0.83 NISCH (0.78) NISCHMTORADKKDM4EALDH1A1
SCHEMBL3399083 0.83 KIF11 (0.54) NISCHMTORADKKDM4EALDH1A1
SCHEMBL862114 0.81 NISCH (0.75) NISCHMTORADKKDM4EALDH1A1
SCHEMBL1719475 0.81 NISCH (0.47) NISCHMTORADKKDM4EALDH1A1
SCHEMBL12632136 0.81 NISCH (0.63) NISCHMTORADKKDM4EALDH1A1
SCHEMBL1719134 0.79 MRGPRX4 (0.58) NISCHMTORADKKDM4EALDH1A1
SCHEMBL771236 0.78 NISCH (0.64) NISCHMTORADKKDM4EALDH1A1
SCHEMBL4659327 0.77 TOP1 (0.42) KDM4EALDH1A1KIF11MRGPRX4ATM
SCHEMBL1688472 0.77 NISCH (0.68) NISCHMTORADKKDM4EALDH1A1
SCHEMBL1719845 0.77 NISCH (0.49) NISCHMTORADKKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113745539-B Fluorine-containing non-noble metal oxygen reduction electrocatalyst and preparation method and application thereof 大连理工大学 2022-11-22 CN claimed
CN-113745539-A Fluorine-containing non-noble metal oxygen reduction electrocatalyst and preparation method and application thereof 大连理工大学 2021-12-03 CN claimed
CN-107835814-B Azabenzimidazoles and their use as AMPA receptor modulators 詹森药业有限公司 2021-07-23 CN claimed
JP-2002541077-A 2002-12-03 JP claimed
EP-1169005-A2 ASSOCIATION OF NO-SYNTHASE INHIBITOR(S) AND METABOLIC ANTIOXIDANT(S) SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2002-01-09 EP claimed
WO-2000059448-A2 ASSOCIATION OF NO-SYNTHASE INHIBITOR(S) AND METABOLIC ANTIOXIDANT(S) SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2000-10-12 WO claimed
US-20250188072-A1 COMPOUNDS FOR TREATMENT OF CANCER UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2025-06-12 US disclosed
US-12187720-B2 Compounds for treatment of cancer UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2025-01-07 US disclosed
US-20240417383-A1 PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF THE SALK INSTITUTE FOR BIOLOGICAL STUDIES 2024-12-19 US disclosed
CN-113024467-B PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof 米托布里奇公司 2024-08-06 CN disclosed
EP-3770146-B1 PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF ASTELLAS ENG SMALL MOLECULES US INCORPORATED (US) 2024-07-24 EP disclosed
CN-113004205-B PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof 米托布里奇公司 2024-07-02 CN disclosed
US-20230373948-A1 PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF Astellas Engineered Small Molecules US, Incorporated 2023-11-23 US disclosed
US-20050234239-A1 Method of forming a carbon-carbon or carbon-heteroatom linkage SHASUN PHARMA SOLUTIONS, INC. 2005-10-20 US disclosed
EP-1585726-A1 FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS ELI LILLY AND COMPANY (US) 2005-10-19 EP disclosed
WO-2004063155-A1 FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS ELI LILLY AND COMPANY (US) 2004-07-29 WO disclosed
US-20030236413-A1 Catalysis in presence of a metallic element, an imine ligand and nitrogen compound as chelating compound, forming a chemical intermediates in the agrochemical and pharmaceutical fields SHASUN PHARMA SOLUTIONS, INC. 2003-12-25 US disclosed
EP-1337516-A1 PROCESS FOR MANUFACTURE OF IMIDAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-08-27 EP disclosed
WO-2002040454-A1 PROCESS FOR MANUFACTURE OF IMIDAZOLES THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 2002-05-23 WO disclosed
WO-2001057038-A9 HETEROCYCLIC COMPOUNDS AND THEIR USE AS PARP INHIBITORS BASF AG (DE) 2001-09-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12187720-B2 Compounds for treatment of cancer KLK3, BRDT, ACP3 NISCH 3272/4885MTOR 1294/4885ADK 2226/4885
US-20050234239-A1 Method of forming a carbon-carbon or carbon-heteroatom linkage AOC1, AOC3, NUDT1 NISCH 53/4885MTOR 4043/4885ADK 2247/4885
US-20030236413-A1 Catalysis in presence of a metallic element, an imine ligand and nitrogen compound as chelating compound, forming a chemical intermediates in the agrochemical and pharmaceutical fields ALK, INMT, ACHE NISCH 188/4885MTOR 3697/4885ADK 675/4885
US-20240417383-A1 PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF PPARG, PPARD, PPARA NISCH 4175/4885MTOR 3100/4885ADK 691/4885
US-20230373948-A1 PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF PPARG, PPARD, PPARA NISCH 4175/4885MTOR 3100/4885ADK 691/4885
US-20250188072-A1 COMPOUNDS FOR TREATMENT OF CANCER KLK3, BRDT, ACP3 NISCH 3272/4885MTOR 1294/4885ADK 2226/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.