Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | UBE2N | P61088 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723506 | 0.88 | MAPT (0.55) | ALDH1A1KDM4ESMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL7730172 | 0.87 | LMNA (0.51) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL7725155 | 0.87 | JAK2 (0.47) | ALDH1A1KDM4EKMT2AHTTMAPT | |
| SCHEMBL7724719 | 0.85 | JAK2 (0.45) | ALDH1A1KDM4ESMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL7726296 | 0.83 | JAK2 (0.45) | ALDH1A1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL7720154 | 0.82 | JAK2 (0.44) | ALDH1A1KDM4EKMT2AHTTMAPT | |
| SCHEMBL7724650 | 0.82 | RAB9A (0.49) | ALDH1A1KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL7720252 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KDM4EKMT2AHTTMAPT | |
| SCHEMBL7720270 | 0.80 | MAPT (0.59) | ALDH1A1SMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL7723582 | 0.80 | ALDH1A1 (0.44) | ALDH1A1KDM4ESMN1; SMN2KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |