Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ACR | P10323 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7730172 | 0.90 | LMNA (0.51) | RAB9APOLBLMNAKDM4EALDH1A1 | |
| SCHEMBL7726296 | 0.85 | JAK2 (0.45) | RAB9ANPC1ACRLMNAKDM4E | |
| SCHEMBL7725155 | 0.83 | JAK2 (0.47) | RAB9ANPC1LMNAKDM4EALDH1A1 | |
| SCHEMBL7730164 | 0.82 | ADORA2A (0.54) | RAB9ANPC1POLBKDM4EALDH1A1 | |
| SCHEMBL7723640 | 0.82 | ALDH1A1 (0.52) | NPC1POLBLMNAKDM4EALDH1A1 | |
| SCHEMBL7724719 | 0.81 | JAK2 (0.45) | RAB9ANPC1LMNAKDM4EALDH1A1 | |
| SCHEMBL7720154 | 0.80 | JAK2 (0.44) | RAB9ANPC1POLBLMNAKDM4E | |
| SCHEMBL7726424 | 0.80 | KMT2A (0.54) | POLBLMNAKDM4EALDH1A1KMT2A | |
| SCHEMBL7720252 | 0.79 | ALDH1A1 (0.47) | RAB9ANPC1LMNAKDM4EALDH1A1 | |
| SCHEMBL7720270 | 0.78 | MAPT (0.59) | RAB9ANPC1LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |