SCHEMBL7730665

SCHEMBL7730665

CCc1cc(F)c(C(F)(F)Oc2ccc(-c3cc(F)c(OC(F)(F)F)c(F)c3)cc2)c(F)c1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PRMT6 Q96LA8 1/20 0.38
AURKA O14965 1/20 0.36
TPX2 Q9ULW0 1/20 0.36
PPARD Q03181 2/20 0.35
PPARA Q07869 2/20 0.35
KIF11 P52732 1/20 0.35
FFAR4 Q5NUL3 2/20 0.35
PTGER4 P35408 1/20 0.35
FFAR1 O14842 1/20 0.35
CNR1 P21554 1/20 0.35
TSHR P16473 1/20 0.35
CHRNA7 P36544 1/20 0.34
AKR1C2 P52895 1/20 0.34
AKR1C1 Q04828 1/20 0.34
DHODH Q02127 1/20 0.33
GRM2 Q14416 1/20 0.33
IDH1 O75874 1/20 0.33
MRGPRX4 Q96LA9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7728916 0.90 FFAR4 (0.36) PRMT6AURKATPX2PPARDPPARA
SCHEMBL7732093 0.89 PRMT6 (0.36) PRMT6AURKATPX2PPARDPPARA
SCHEMBL7732941 0.88 PRMT6 (0.35) PRMT6AURKATPX2PPARDPPARA
SCHEMBL7732787 0.88 FFAR4 (0.35) PRMT6AURKATPX2PPARDPPARA
SCHEMBL7734977 0.87 DAO (0.40) PPARDPPARAFFAR4TSHR
SCHEMBL7730618 0.87 RARB (0.39) PRMT6PPARDPPARAFFAR4FFAR1
SCHEMBL7730134 0.86 PRMT6 (0.32) PRMT6FFAR4FFAR1
SCHEMBL7730988 0.86 PDE2A (0.33) PPARDPPARATSHR
SCHEMBL7732166 0.86 PPARD (0.35) PPARDPPARAKIF11TSHRMRGPRX4
SCHEMBL7734971 0.85 PRMT6 (0.39) PRMT6AURKATPX2PPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed
EP-0786445-A1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1997-07-30 EP disclosed