SCHEMBL7732941

SCHEMBL7732941

CCc1cc(F)c(C(F)(F)Oc2ccc(-c3cc(F)c(F)c(F)c3)cc2)c(F)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT6 Q96LA8 1/20 0.35
MAOB P27338 1/20 0.33
AURKA O14965 1/20 0.33
TPX2 Q9ULW0 1/20 0.33
PPARD Q03181 2/20 0.32
PPARA Q07869 2/20 0.32
PTGER4 P35408 1/20 0.32
PPARG P37231 1/20 0.32
KIF11 P52732 1/20 0.32
RXRA P19793 1/20 0.32
RXRB P28702 1/20 0.32
ANPEP P15144 5/20 0.32
RARA P10276 1/20 0.32
RARB P10826 1/20 0.32
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
TSHR P16473 1/20 0.31
P2RX7 Q99572 1/20 0.31
AKR1C2 P52895 1/20 0.31
AKR1C1 Q04828 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7732093 0.93 PRMT6 (0.36) PRMT6AURKATPX2PPARDPPARA
SCHEMBL7732784 0.89 RARB (0.33) PRMT6MAOBPPARDPPARAPPARG
SCHEMBL15965522 0.89 KIF11 (0.33) PRMT6KIF11RXRARXRBANPEP
SCHEMBL17736129 0.89 KIF11 (0.33) PRMT6KIF11RXRARXRBANPEP
SCHEMBL7730665 0.88 PRMT6 (0.38) PRMT6AURKATPX2PPARDPPARA
SCHEMBL7733314 0.87 RARB (0.36) PRMT6MAOBPPARDPPARAPPARG
SCHEMBL7722585 0.86 DAO (0.36) MAOBTSHRP2RX7
SCHEMBL7735200 0.86 RARB (0.41) PPARAPPARGRARARARBTSHR
SCHEMBL7731445 0.86 DHODH (0.33) PRMT6KIF11CYP11B1CYP11B2
SCHEMBL7731620 0.85 MAOB (0.32) MAOBP2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed
EP-0786445-A1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1997-07-30 EP disclosed