SCHEMBL7734069

SCHEMBL7734069

O=C(ONCc1ccc(-c2ccccc2)cc1)C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.46
ALDH1A1 P00352 1/20 0.46
FFAR1 O14842 3/20 0.44
EPHX2 P34913 1/20 0.44
NR1H4 Q96RI1 1/20 0.44
HTT P42858 2/20 0.44
RAB9A P51151 2/20 0.44
HDAC1 Q13547 5/20 0.43
HDAC2 Q92769 5/20 0.43
HDAC3 O15379 4/20 0.43
HDAC4 P56524 4/20 0.43
HDAC7 Q8WUI4 4/20 0.43
HDAC10 Q969S8 4/20 0.43
HDAC11 Q96DB2 4/20 0.43
HDAC8 Q9BY41 4/20 0.43
HDAC6 Q9UBN7 4/20 0.43
HDAC9 Q9UKV0 4/20 0.43
HDAC5 Q9UQL6 4/20 0.43
ABCC4 O15439 1/20 0.43
GAA P10253 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5450071 0.90 CES1 (0.52) LMNAALDH1A1HDAC1HDAC3HDAC4
SCHEMBL3507989 0.82 TRPV1 (0.45) EPHX2HDAC1HDAC2HDAC3HDAC4
SCHEMBL4936119 0.79 LMNA (0.52) LMNAALDH1A1FFAR1EPHX2NR1H4
SCHEMBL6317990 0.78 HDAC3 (0.54) ALDH1A1EPHX2NR1H4RAB9AHDAC1
SCHEMBL7058052 0.76 HDAC1 (0.49) ALDH1A1HTTRAB9AHDAC1HDAC2
SCHEMBL27812214 0.76 HDAC1 (0.45) LMNAALDH1A1FFAR1HTTRAB9A
SCHEMBL5758191 0.75 RORC (0.47)
SCHEMBL29249471 0.74 MLYCD (0.50) ALDH1A1RAB9AHDAC1HDAC3HDAC4
SCHEMBL27498230 0.73 SMN1; SMN2 (0.47) LMNAEPHX2RAB9ACA1CA2
SCHEMBL583920 0.73 CES1 (0.78) LMNAALDH1A1FFAR1HTTHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6399629-B1 PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY MICROCIDE PHARMACEUTICALS, INC. 2002-06-04 US disclosed
WO-2000001714-A1 EFFLUX PUMP INHIBITORS MICROCIDE PHARMACEUTICALS, INC. (US) 2000-01-13 WO disclosed