Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7731671 | 0.83 | SIGMAR1 (0.59) | HTR1ADRD2HTR2ASLC6A2SLC6A4 | |
| SCHEMBL7732468 | 0.81 | HTR1A (0.52) | HTR1ADRD2HTR2ASLC6A2SLC6A4 | |
| SCHEMBL7731021 | 0.81 | CYP3A4 (0.45) | DRD2RAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL7733541 | 0.80 | HTR2A (0.60) | HTR1ADRD2HTR2ASLC6A2SLC6A4 | |
| SCHEMBL19852051 | 0.75 | CARM1 (0.64) | HTR1ADRD2HTR2ASLC6A4SLC6A3 | |
| SCHEMBL9237144 | 0.71 | LMNA (0.52) | CARM1PRMT6LMNASIGMAR1MAOA | |
| SCHEMBL13533153 | 0.71 | HTR1A (0.65) | HTR1ADRD2HTR2ASLC6A2SLC6A4 | |
| SCHEMBL27919179 | 0.70 | DRD2 (0.61) | HTR1ADRD2HTR2ASLC6A2SLC6A4 | |
| SCHEMBL28636881 | 0.69 | RAB9A (0.56) | DRD2RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL21186301 | 0.69 | CYP3A4 (0.59) | SLC6A2SLC6A3RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407122-B1 | NEUROPROTECTIVE AGENTS, ANTIISCHEMIC, AND HYPERGLYCEMIC AGENTS; HUNTINGTON*S, PARKINSON*S, AND ALZHEIMER*S DISEASE;AMYOTROPHIC LATERAL SCLEROSIS TREATMENT; NERVOUS SYSTEM AND BRAIN DISORDERS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-06-18 | — | — | US | disclosed |
| EP-1037890-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999028318-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |