Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.81 |
| ▸ | LMNA | P02545 | 3/20 | 0.81 |
| ▸ | HTT | P42858 | 1/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | UBE2N | P61088 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7738147 | 0.81 | ALDH1A1 (0.81) | LMNAHTTALDH1A1NPC1USP2 | |
| SCHEMBL17731134 | 0.79 | DRD4 (0.67) | SMN1; SMN2LMNAHTTALDH1A1NPC1 | |
| SCHEMBL7738167 | 0.77 | ALDH1A1 (1.00) | SMN1; SMN2LMNAALDH1A1NPC1USP2 | |
| SCHEMBL7735984 | 0.76 | ALDH1A1 (0.67) | SMN1; SMN2ALDH1A1NPC1USP2HPGD | |
| SCHEMBL8958804 | 0.76 | SMN1; SMN2 (0.72) | SMN1; SMN2LMNAHTTALDH1A1POLB | |
| SCHEMBL22777878 | 0.75 | ALDH1A1 (0.60) | SMN1; SMN2LMNAHTTALDH1A1NPC1 | |
| SCHEMBL26154118 | 0.75 | HDAC8 (0.76) | SMN1; SMN2HTTNPC1MAPK1 | |
| SCHEMBL3454062 | 0.75 | ALDH1A1 (0.73) | SMN1; SMN2LMNAHTTALDH1A1KDM4E | |
| SCHEMBL7476441 | 0.75 | LMNA (0.64) | SMN1; SMN2LMNAHTTALDH1A1KDM4E | |
| SCHEMBL3379373 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048900-A | FOR TREATING EATING DISORDERS, INSULIN RESISTANT DIABETES, HYPERTENSION, HYPERLIPEMIA | BAYER CORPORATION (US) | 2000-04-11 | — | — | US | disclosed |