Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | MEN1 | O00255 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27525664 | 0.83 | RXFP1 (0.35) | SYKALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL27493987 | 0.80 | ALDH1A1 (0.33) | SYKALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7740422 | 0.78 | SYK (0.40) | SYKALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL22044797 | 0.76 | NR1I3 (0.43) | SYKALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL27506223 | 0.72 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL22044738 | 0.70 | NAMPT (0.44) | SYKALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL27564255 | 0.68 | NTRK1 (0.31) | — | |
| SCHEMBL27495566 | 0.68 | GPR119 (0.35) | KCNH2CYP2C8CYP2C9 | |
| SCHEMBL7738864 | 0.67 | SYK (0.35) | SYKALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7734196 | 0.67 | HDAC3 (0.32) | ALDH1A1MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1217928-C | Heterocyclic compound having NOS inhibitory action | CHUGAI SEIYAKA K K (JP) | 2005-09-07 | — | — | CN | disclosed |
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | disclosed |
| CN-1280565-A | Heterocyclic compounds having NOS inhibitory activities | CHUGAI SEIYAKA K K (JP) | 2001-01-17 | — | — | CN | disclosed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | disclosed |