Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27493987 | 0.84 | ALDH1A1 (0.33) | HDAC3HDAC1TNIKJAK2JAK3 | |
| SCHEMBL27525664 | 0.82 | RXFP1 (0.35) | TNIKRXFP1MEN1ALDH1A1MAPT | |
| SCHEMBL7734198 | 0.80 | TSHR (0.34) | HDAC1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL7738895 | 0.75 | LMNA (0.32) | HDAC3HDAC1MEN1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7738922 | 0.74 | LMNA (0.32) | HDAC3HDAC1MEN1ALDH1A1MAPT | |
| SCHEMBL7740424 | 0.71 | MEN1 (0.36) | RXFP1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL27564255 | 0.70 | NTRK1 (0.31) | — | |
| SCHEMBL27495566 | 0.69 | GPR119 (0.35) | — | |
| SCHEMBL7740420 | 0.67 | SYK (0.37) | RXFP1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL7738864 | 0.66 | SYK (0.35) | HDAC1MEN1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1217928-C | Heterocyclic compound having NOS inhibitory action | CHUGAI SEIYAKA K K (JP) | 2005-09-07 | — | — | CN | disclosed |
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | disclosed |
| CN-1280565-A | Heterocyclic compounds having NOS inhibitory activities | CHUGAI SEIYAKA K K (JP) | 2001-01-17 | — | — | CN | disclosed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | disclosed |