SCHEMBL7740917

SCHEMBL7740917

N#Cc1cc(F)c(-n2c(=O)[nH]c(C(F)(F)F)c(Cl)c2=O)cc1F

nearest known ligand 0.45

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
BCAT1 P54687 17/20 0.45
BCAT2 O15382 15/20 0.45
TRPV4 Q9HBA0 1/20 0.35
ALDH1A1 P00352 1/20 0.34
PGR P06401 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5922790 0.76 BCAT1 (0.67) BCAT1BCAT2
SCHEMBL7537781 0.76 BCAT2 (0.45) BCAT1BCAT2TRPV4ALDH1A1PGR
SCHEMBL7015287 0.74 BCAT1 (0.41) BCAT1BCAT2TRPV4ALDH1A1PGR
SCHEMBL6494272 0.71 BCAT2 (0.38) BCAT1BCAT2TRPV4ALDH1A1PGR
SCHEMBL7653141 0.71 KDM1A (0.33) BCAT1BCAT2TRPV4ALDH1A1
SCHEMBL7696171 0.69 BCAT1 (0.53) BCAT1BCAT2ALDH1A1
SCHEMBL9023737 0.69 MAPT (0.44) BCAT1BCAT2TRPV4ALDH1A1
SCHEMBL24824865 0.68 BCAT1 (0.66) BCAT1BCAT2
SCHEMBL22495466 0.68 HTT (0.40) BCAT1BCAT2
SCHEMBL8193759 0.68 BCAT2 (0.40) BCAT1BCAT2TRPV4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6417141-B1 HERBICIDES AND TO NOVEL INTERMEDIATES. BAYER AKTIENGESELLSCHAFT (DE) 2002-07-09 US disclosed