Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720186 | 1.00 | CRBN (0.32) | CRBN | |
| SCHEMBL19651882 | 0.77 | CRBN (0.30) | CRBN | |
| SCHEMBL2689523 | 0.69 | — | — | |
| SCHEMBL15660011 | 0.65 | CRBN (0.35) | CRBN | |
| SCHEMBL6869846 | 0.65 | — | — | |
| SCHEMBL2691519 | 0.65 | — | — | |
| SCHEMBL19983917 | 0.65 | MAPT (0.36) | — | |
| SCHEMBL20324913 | 0.64 | ALDH1A1 (0.32) | CRBN | |
| SCHEMBL15655709 | 0.63 | CRBN (0.33) | CRBN | |
| SCHEMBL13993769 | 0.62 | SMN1; SMN2 (0.36) | CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074630-B1 | Microbial production of levodione | DSM IP ASSETS BV (NL) | 2012-01-18 | — | — | EP | claimed |
| US-6428991-B1 | (6R)-2,2,6-TRIMETHYLCYCLOHEXANE-1,4-DIONE,A USEFUL INTERMEDIATE IN THE PRODUCTION OF CAROTENOIDS, FROM KETOISOPHORONE (2,6,6-TRIMETHYL-2-CYCLOHEXENE) WITH A YEAST IMMOBILIZED IN A HYDROPHOBIC PHOTO-CROSSLINKABLE RESIN | ROCHE VITAMINS INC. | 2002-08-06 | — | — | US | claimed |
| EP-1074630-A2 | Microbial production of levodione | F. Hoffmann-La Roche AG (CH) | 2001-02-07 | — | — | EP | claimed |
| US-3988205-A | BY FERMENTATIVELY HYDROGENATING AND REDUCING KETOISOPHORONE | HOFFMANN-LA ROCHE INC. (US) | 1976-10-26 | — | — | US | claimed |
| JP-60188082-A | — | — | None | — | — | JP | disclosed |
| US-12618050-B2 | Engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-05-05 | — | — | US | disclosed |
| US-20260043010-A1 | ENONE REDUCTASES | CODEXIS, INC. (US) | 2026-02-12 | — | — | US | disclosed |
| US-12371674-B2 | Enone reductases | CODEXIS, INC. (US) | 2025-07-29 | — | — | US | disclosed |
| EP-4473098-A2 | ENGINEERED ENONE REDUCTASE AND KETOREDUCTASE VARIANT ENZYMES | Codexis, Inc. (US) | 2024-12-11 | — | — | EP | disclosed |
| CN-118647711-A | Engineered enone reductase and ketoreductase variant enzymes | 科德克希思公司 | 2024-09-13 | — | — | CN | disclosed |
| US-11875298-B2 | Sensor for NADP (H) and development of alcohol dehydrogenases | FORSCHUNGSZENTRUM JULICH GMBH (DE) | 2024-01-16 | — | — | US | disclosed |
| US-20230322857-A1 | RECOMBINANTLY ENGINEERED POLYPEPTIDES CAPABLE OF RECYCLING NONCANONICAL COFACTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-10-12 | — | — | US | disclosed |
| US-5201931-A | For seed treatment, promoting cold and/or freezing resistance | HER MAJESTY THE QUEEN IN RIGHT OF CANADA, AS REPRESENTED BY THE NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 1993-04-13 | — | — | US | disclosed |
| EP-0371882-A2 | Abscisic acid-related plant growth regulators - germination promoters | HER MAJESTY IN RIGHT OF CANADA AS REPRESENTED BY THE NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 1990-06-06 | — | — | EP | disclosed |
| JP-S60188082-A | PREPARATION OF (2S)-2-HYDROXY-2,6,6-TRIMETHYL-1,4- CYCLOHEXANEDIONE AND AGENT FOR IMPROVING TASTE AND FLAVOR OF TOBACCO COMPOSED OF SAID COMPOUND | JAPAN TOBACCO INC | 1985-09-25 | — | — | JP | disclosed |
| US-4156100-A | INTERMEDIATES FOR OPTICALLY ACTIVE CAROTENOIDS | HOFFMANN-LA ROCHE INC. (US) | 1979-05-22 | — | — | US | disclosed |
| US-4095038-A | INTERMEDIATES IN THE PRODUCTION OF CAROTENOIDS | HOFFMANN-LA ROCHE INC. (US) | 1978-06-13 | — | — | US | disclosed |
| US-4072715-A | CAROTENOIDS | HOFFMANN-LA ROCHE INC. (US) | 1978-02-07 | — | — | US | disclosed |
| US-4026949-A | INTERMEDIATES FOR CAROTENOIDS | HOFFMANN-LA ROCHE INC. (US) | 1977-05-31 | — | — | US | disclosed |
| US-3988205-A | BY FERMENTATIVELY HYDROGENATING AND REDUCING KETOISOPHORONE | HOFFMANN-LA ROCHE INC. (US) | 1976-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12371674-B2 | Enone reductases | ENO1, DCXR, RRM2B | CRBN 3518/4885 |
| US-12618050-B2 | Engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and uses thereof | NNMT, NAPRT, NQO1 | CRBN 1680/4885 |
| US-20260043010-A1 | ENONE REDUCTASES | DCXR, ENY2, UPF1 | CRBN 2828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.