Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.55 |
| ▸ | CTSS | P25774 | 3/20 | 0.55 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 6/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7742011 | 1.00 | CTSL (0.55) | CTSLCTSSPSMB1SIRT2ALDH1A1 | |
| SCHEMBL22975021 | 0.88 | CTSL (0.57) | CTSLCTSSSIRT2ALDH1A1CYP3A4 | |
| SCHEMBL28678129 | 0.88 | CTSL (0.57) | CTSLCTSSSIRT2ALDH1A1CYP3A4 | |
| SCHEMBL7742003 | 0.88 | PSMB1 (0.56) | CTSLCTSSPSMB1ALDH1A1CTSK | |
| SCHEMBL7742845 | 0.88 | PSMB1 (0.56) | CTSLCTSSPSMB1ALDH1A1CTSK | |
| SCHEMBL7688519 | 0.87 | PSMB1 (0.57) | CTSLCTSSPSMB1CTSKCASP1 | |
| Hydrochloric Acid SCHEMBL29604804 | 0.87 | CTSL (0.56) | CTSLCTSSSIRT2ALDH1A1CYP3A4 | |
| SCHEMBL2026643 | 0.86 | SIRT2 (0.52) | CTSLCTSSPSMB1SIRT2ALDH1A1 | |
| SCHEMBL6254290 | 0.85 | CASP1 (0.57) | CTSLCTSSALDH1A1CYP3A4TSHR | |
| SCHEMBL4452037 | 0.85 | CASP1 (0.57) | CTSLCTSSALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420166-B2 | REACTING AN N-PROTECTED ASPARAGINE ESTER WITH A PROTEASE IN AQUEOUS SOLUTION AT PH OF 6.0 TO 7.5 AND AN ORGANIC SOLVENT, AND EXTRACTING THE N-PROTECTED-D-ASPARAGINE ESTER; CHEMICAL INTERMEDIATES TO ANTIBACTERIAL COMPOUNDS | BASOLEA PHARMACEUTICA AG (CH) | 2002-07-16 | — | — | US | disclosed |
| US-20010049127-A1 | Process for the preparation of D-asparagine derivatives | HOFFMANN-LA ROCHE INC. | 2001-12-06 | — | — | US | disclosed |
| EP-1148140-A1 | Process for the preparation of D-asparagine derivatives | Basilea Pharmaceutica AG (CH) | 2001-10-24 | — | — | EP | disclosed |