Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 17/20 | 0.66 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.66 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.66 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | PPARD | Q03181 | 1/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24601182 | 0.88 | ADORA3 (0.78) | ADORA3ADORA1ADORA2AADORA2BHTR2C | |
| SCHEMBL19370184 | 0.86 | NT5E (0.65) | ADORA3ADORA1ADORA2A | |
| SCHEMBL8327419 | 0.85 | ALDH1A1 (0.53) | ADORA3ADORA1ADORA2AADORA2BTP53 | |
| SCHEMBL7744287 | 0.84 | ADORA3 (0.62) | ADORA3ADORA1ADORA2AADORA2BHTR2C | |
| SCHEMBL9404051 | 0.84 | ALDH1A1 (0.51) | ADORA3ADORA1ADORA2ATP53MAPT | |
| SCHEMBL8819182 | 0.84 | ALDH1A1 (0.51) | ADORA3ADORA1ADORA2ATP53MAPT | |
| SCHEMBL8820179 | 0.83 | ALDH1A1 (0.50) | ADORA3ADORA1ADORA2ATP53MAPT | |
| SCHEMBL23436497 | 0.82 | LMNA (0.69) | TP53MAPT | |
| SCHEMBL8818839 | 0.82 | LMNA (0.69) | TP53MAPT | |
| SCHEMBL15679138 | 0.82 | LMNA (0.69) | TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708781-B1 | A 3 ADENOSINE RECEPTOR AGONISTS | USA (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-0708781-A1 | A 3 ADENOSINE RECEPTOR AGONISTS | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995002604-A1 | A3 ADENOSINE RECEPTOR AGONISTS | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1995-01-26 | — | — | WO | disclosed |