SCHEMBL7744256

SCHEMBL7744256

COc1ccc(S(=O)(=O)CC(O)(O)C(N)=O)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 6/20 0.55
HTT P42858 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
MMP1 P03956 4/20 0.49
F2 P00734 3/20 0.47
PRSS1 P07477 3/20 0.47
PRSS2 P07478 3/20 0.47
PRSS3 P35030 3/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
MMP8 P22894 1/20 0.46
PKM P14618 1/20 0.46
HSD11B1 P28845 1/20 0.46
ALDH1A1 P00352 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
MAPT P10636 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
CA12 O43570 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7748825 0.82 MMP13 (0.60) MMP13MMP1MMP8ALDH1A1CA12
SCHEMBL7076712 0.78 MMP13 (0.83) MMP13HTTNPSR1MMP1MEN1
SCHEMBL7210477 0.76 MMP1 (0.57) MMP13HTTNPSR1MMP1MEN1
SCHEMBL7077700 0.74 MMP13 (0.71) MMP13HTTNPSR1MMP1MEN1
SCHEMBL7748901 0.74 MMP13 (0.61) MMP13MMP1MEN1KMT2AMMP8
SCHEMBL7647099 0.74 MMP13 (0.57) MMP13HTTNPSR1MMP1MEN1
SCHEMBL7080540 0.73 HTT (0.62) MMP13HTTNPSR1MMP1MEN1
SCHEMBL7210446 0.73 MMP13 (0.50) MMP13HTTNPSR1MMP1MMP8
SCHEMBL8843464 0.72 HTT (0.57) MMP13HTTNPSR1MMP1MEN1
SCHEMBL9703007 0.72 HTT (0.66) MMP13HTTNPSR1MMP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0984959-A4 AROMATIC SULFONYL ALPHA-HYDROXY HYDROXAMIC ACID COMPOUNDS MONSANTO CO (US) 2001-05-02 EP disclosed
EP-0984959-A1 AROMATIC SULFONYL ALPHA-HYDROXY HYDROXAMIC ACID COMPOUNDS MONSANTO COMPANY (US) 2000-03-15 EP disclosed
WO-1998039326-A1 AROMATIC SULFONYL ALPHA-HYDROXY HYDROXAMIC ACID COMPOUNDS MONSANTO COMPANY (US) 1998-09-11 WO disclosed